Meeting Banner
Abstract #0524

Sensitive Quantification of Hypomyelination and Axon g-ratio UsingĀ Ultra High Resolution 7T Multi-Echo Gradient Echo MRI with BSS-rPCA

Vladimir Grouza1,2, Hooman Bagheri3, Marius Tuznik1,2, Hanwen Liu1,2, Alan C Peterson2,3,4, and David A Rudko1,2,5
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, 2Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 3Department of Human Genetics, McGill University, Montreal, QC, Canada, 4Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada, 5Department of Biomedical Engineering, McGill University, Montreal, QC, Canada


We investigated the application of blind source separation, robust principal component analysis (BSS-rPCA) for myelin water imaging in a panel of mice exhibiting varied myelination profiles. BSS-rPCA exhibited sensitivity to myelin as evidenced by region of interest (ROI) analysis of several white matter tracts as a function of hypomyelinating genotype. By combining BSS-rPCA with estimates of neurite orientation dispersion and density imaging (NODDI)-derived axon water fraction (AWF) maps, we conclude that BSS-rPCA is sensitive to variations in myelin content in the presence of stable axon density.

This abstract and the presentation materials are available to members only; a login is required.

Join Here