Abstract #0524

Sensitive Quantification of Hypomyelination and Axon g-ratio Using Ultra High Resolution 7T Multi-Echo Gradient Echo MRI with BSS-rPCA

Vladimir Grouza^1,2, Hooman Bagheri³, Marius Tuznik^1,2, Hanwen Liu^1,2, Alan C Peterson^2,3,4, and David A Rudko^1,2,5

¹McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ²Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, ³Department of Human Genetics, McGill University, Montreal, QC, Canada, ⁴Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada, ⁵Department of Biomedical Engineering, McGill University, Montreal, QC, Canada

Synopsis

We investigated the application of blind source separation, robust principal component analysis (BSS-rPCA) for myelin water imaging in a panel of mice exhibiting varied myelination profiles. BSS-rPCA exhibited sensitivity to myelin as evidenced by region of interest (ROI) analysis of several white matter tracts as a function of hypomyelinating genotype. By combining BSS-rPCA with estimates of neurite orientation dispersion and density imaging (NODDI)-derived axon water fraction (AWF) maps, we conclude that BSS-rPCA is sensitive to variations in myelin content in the presence of stable axon density.

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