Abstract #0525

Along-tract quantification of the BOLD hemodynamic response function in white matter

Kurt G Schilling¹, Muwei Li¹, Francois Rheault², Yurui Gao², Zhaohua Ding², Adam W Anderson², Hakmook Kang², Bennett A Landman², and John C Gore¹

¹Vanderbilt University Medical Center, Nashville, TN, United States, ²Vanderbilt University, Nashville, TN, United States

Synopsis

We measured the variations of the BOLD hemodynamic response function (HRF) along white matter (WM) pathways. We find that the WM HRF is different to that of the gray matter (GM), and has a prominent negative dip and smaller peak signal. Further, we find that the HRF changes along WM pathways, and is different between pathways. Characterizing the variations of the WM HRF along and across pathways may provide insight into the biophysical basis of BOLD effects in WM and the relationships between WM structure and neurovascular coupling.

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