Abstract #0527

Functional activities detected in the olfactory bulb and associated olfactory regions in the human brain using T2-prepared BOLD fMRI at 7T

Xinyuan Miao^1,2, Adrian G. Paez^1,2, Suraj Rajan³, Di Cao^1,2,4, Dapeng Liu^1,2, Alex Y. Pantelyat³, Liana I. Rosenthal³, Peter C.M. van Zijl^1,2, Susan S. Bassett⁵, David M. Yousem⁶, Vidyulata Kamath⁵, and Jun Hua^1,2

¹Neurosection, Division of MRI Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Conventional EPI-based BOLD fMRI can be challenging in olfaction related brain regions, such as the olfactory bulb (OB), mainly due to the large susceptibility artifacts. To date, few studies have demonstrated successful fMRI in the human OB. T2-prepared (T2prep) BOLD fMRI is an alternative approach developed especially for reducing such susceptibility artifacts. Here, olfactory fMRI was performed at 7T in 14 healthy participants. T2prep-BOLD showed greater functional sensitivity than GRE-EPI-BOLD in the OB and associated olfactory regions. Habituation effects and a bi-phasic pattern of fMRI signal changes were observed using T2prep-BOLD, which showed a good intra-subject reproducibility.

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