Abstract #0527
Functional activities detected in the olfactory bulb and associated olfactory regions in the human brain using T2-prepared BOLD fMRI at 7T
Xinyuan Miao1,2, Adrian G. Paez1,2, Suraj Rajan3, Di Cao1,2,4, Dapeng Liu1,2, Alex Y. Pantelyat3, Liana I. Rosenthal3, Peter C.M. van Zijl1,2, Susan S. Bassett5, David M. Yousem6, Vidyulata Kamath5, and Jun Hua1,2
1Neurosection, Division of MRI Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
Synopsis
Conventional EPI-based BOLD fMRI can be challenging in olfaction related brain regions, such as the olfactory bulb (OB), mainly due to the large susceptibility artifacts. To date, few studies have demonstrated successful fMRI in the human OB. T2-prepared (T2prep) BOLD fMRI is an alternative approach developed especially for reducing such susceptibility artifacts. Here, olfactory fMRI was performed at 7T in 14 healthy participants. T2prep-BOLD showed greater functional sensitivity than GRE-EPI-BOLD in the OB and associated olfactory regions. Habituation effects and a bi-phasic pattern of fMRI signal changes were observed using T2prep-BOLD, which showed a good intra-subject reproducibility.
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