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Abstract #0529

The Relative Contribution of the Vascular Architecture and Reactivity to the BOLD signal Formation

Emiel C.A. Roefs1, Wouter Schellekens1, Mario G. Báez-Yáñez1, Alex A. Bhogal1, Jeroen C.W. Siero1,2, and Natalia Petridou1
1Radiology department, Center for Image Sciences, UMC Utrecht, Utrecht, Netherlands, 2Spinoza Center for Neuroimaging, Amsterdam, Netherlands


In this study, we investigate the vascular contribution to the BOLD signal by comparing purely non-neuronal-related changes in the BOLD signal induced by gas manipulations with neuronal-related hemodynamic changes in the BOLD signal for different vascular compartments. Different vascular compartments were targeted by employing gradient-echo and spin-echo in combination with cortical depth estimations and pial vein segmentations. Our findings suggest that the increase in macro-vascular baseline venous blood volume (CBVv0) is the main contributor to the large GE-BOLD signal increase towards the pial surface and that normalization for this CBVv0-dependence is possible using a hyperoxia breathing task.

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