Non-invasive imaging of cerebral oxygen delivery and consumption is crucial to understand neurovascular coupling and oxidative metabolism. We combine NIRS and MRI to determine the correlation between mitochondrial status and perfusion in the cortex of mice, when exposed to hypercapnia or varying oxygen levels. There was no correlation between perfusion and redox state under hypercapnia, while a strong correlation was observed under varying oxygen levels. This proves that the relationship between perfusion and mitochondrial redox can be quantified non-invasively in vivo. Such simultaneous measurements, in neurovascular diseases, will help determine whether there is abnormal neurovascular coupling or abnormal oxidative metabolism.
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