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Abstract #0530

The relationship between cytochrome oxidase redox state and CBF is not constant: A multimodal 9.4T NIRS-MRI study on animal model

Mada Hashem1,2,3,4, Ying Wu2,3,4, and Jeff F. Dunn2,3,4
1Biomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada, 2Department of Radiology, University of Calgary, Calgary, AB, Canada, 3Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 4Experimental Imaging Centre, University of Calgary, Calgary, AB, Canada


Non-invasive imaging of cerebral oxygen delivery and consumption is crucial to understand neurovascular coupling and oxidative metabolism. We combine NIRS and MRI to determine the correlation between mitochondrial status and perfusion in the cortex of mice, when exposed to hypercapnia or varying oxygen levels. There was no correlation between perfusion and redox state under hypercapnia, while a strong correlation was observed under varying oxygen levels. This proves that the relationship between perfusion and mitochondrial redox can be quantified non-invasively in vivo. Such simultaneous measurements, in neurovascular diseases, will help determine whether there is abnormal neurovascular coupling or abnormal oxidative metabolism.

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