Abstract #0546

APTw imaging outperforms relaxation-compensated CEST-MRI at 3T in assessing glioma progression after radiotherapy - a preliminary analysis

Nikolaus von Knebel Doeberitz¹, Florian Kroh², Johannes Breitling², Srdjan Maksimovic¹, Laila Koenig³, Juergen Debus^3,4, Peter Bachert^2,5, Heinz-Peter Schlemmer^1,6, Mark E. Ladd^2,5,6, Steffen Goerke², and Daniel Paech^1,7

¹Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany, ⁴Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵Department of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, ⁶Faculty of Medicine, University of Heidelberg, Heidelberg, Germany, ⁷Department of Neuroradiology, Bonn University Hospital, Bonn, Germany

Synopsis

In this interim analysis we compared in patients with gliomas the ability of asymmetry-based amide proton transfer weighted (APTw) imaging with Lorentzian-fit-based relaxation-compensated CEST-MRI (MTR_Rex) of the APT, rNOE and MT signal to differentiate disease progression from treatment induced changes six weeks after completion of radiotherapy. In progressive gliomas, APTw displayed significantly higher signal intensities in contrast enhancing tissue compared to non-progressive gliomas with an AUC of 0.77 in receiver operator characteristic analyses (p 0.03). MT_MTRrex showed a trend towards higher signal intensities in progressive tumors. All CEST metrics displayed significant differences in white and gray brain matter signal intensities.

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