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Abstract #0547

MR Molecular Imaging of Extradomain-B Fibronectin for Non-invasive Active Surveillance of Prostate Cancer

Amita Vaidya1, Aman Shankardass1, Megan Buford1, Ryan Hall1, and Zheng-Rong Lu1
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States


C-X-C motif chemokine receptor 2 (CXCR2) expression is associated with high-grade and advanced prostate cancer. LNCaP-CXCR2+ prostate cancer cells with stable expression of CXCR2 exhibited mesenchymal features and became more aggressive with elevated expression of an ECM oncoprotein EDB-FN as compared to the slow-growing parental cell line, LNCaP. MRMI of EDB-FN with a targeted contrast agent MT218 resulted in significant increase of T1-weighted contrast enhancement in LNCaP-CXCR2+ prostate tumors as compared to the LNCaP tumors in mice. The results suggest that MRMI of EDB-FN has the potential to provide non-invasive active surveillance of low-grade prostate cancer.

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