Abstract #0548

Diffusion restriction comparison between Gleason 4 fused and cribriform glands within patients using whole mount prostate pathology

Savannah R Duenweg¹, Xi Fang², Samuel A Bobholz¹, Allison K Lowman³, Michael Brehler³, Fitzgerald Kyereme³, Kenneth A Iczkowski⁴, Kenneth Jacobsohn⁵, Anjishnu Banerjee², and Peter S LaViolette^3,6

¹Biophysics, Medical College of Wisconsin, Wauwatosa, WI, United States, ²Biostatistics, Medical College of Wisconsin, Wauwatosa, WI, United States, ³Radiology, Medical College of Wisconsin, Wauwatosa, WI, United States, ⁴Pathology, Medical College of Wisconsin, Wauwatosa, WI, United States, ⁵Urology, Medical College of Wisconsin, Wauwatosa, WI, United States, ⁶Biomedical Engineering, Medical College of Wisconsin, Wauwatosa, WI, United States

Synopsis

This study used prostate histology and multi-parametric magnetic resonance imaging (MP-MRI) to evaluate diffusion differences in Gleason pattern 4 gland morphology. After surgery, tissue was sliced using slicing jigs, annotated by a board-certified pathologist, and digitally contoured to differentiate lumen and epithelium. Slides were co-registered to the T2-weighted MRI scan. Two linear mixed models were fitted to the MP-MRI data to consider the different hierarchical structures. Model (1) considers patient as random effect, and Model (2) adds a nested effect for slide. We found that cribriform glands were more diffusion restricted than fused glands in Gleason Grade 4 tumors.

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