Abstract #0548
Diffusion restriction comparison between Gleason 4 fused and cribriform glands within patients using whole mount prostate pathology
Savannah R Duenweg1, Xi Fang2, Samuel A Bobholz1, Allison K Lowman3, Michael Brehler3, Fitzgerald Kyereme3, Kenneth A Iczkowski4, Kenneth Jacobsohn5, Anjishnu Banerjee2, and Peter S LaViolette3,6
1Biophysics, Medical College of Wisconsin, Wauwatosa, WI, United States, 2Biostatistics, Medical College of Wisconsin, Wauwatosa, WI, United States, 3Radiology, Medical College of Wisconsin, Wauwatosa, WI, United States, 4Pathology, Medical College of Wisconsin, Wauwatosa, WI, United States, 5Urology, Medical College of Wisconsin, Wauwatosa, WI, United States, 6Biomedical Engineering, Medical College of Wisconsin, Wauwatosa, WI, United States
Synopsis
This study used prostate histology and multi-parametric magnetic resonance imaging (MP-MRI) to evaluate diffusion differences in Gleason pattern 4 gland morphology. After surgery, tissue was sliced using slicing jigs, annotated by a board-certified pathologist, and digitally contoured to differentiate lumen and epithelium. Slides were co-registered to the T2-weighted MRI scan. Two linear mixed models were fitted to the MP-MRI data to consider the different hierarchical structures. Model (1) considers patient as random effect, and Model (2) adds a nested effect for slide. We found that cribriform glands were more diffusion restricted than fused glands in Gleason Grade 4 tumors.
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