Investigating the contribution of hyaluronan (HA) to the breast tumour microenvironment using multiparametric MRI and histology
Emma L Reeves1, Jin Li1, Konstantinos Zormpas-Petridis1, James Sullivan2, Craig Cummings1, Barbara Blouw3, David Kang3, Ralph Sinkus4, Jeffrey C Bamber1, Yann Jamin1, and Simon P Robinson1
1Radiotherapy & Imaging, Institute of Cancer Research, London, United Kingdom, 2Royal Marsden NHS Foundation Trust, London, United Kingdom, 3Halozyme Therapeutics, San Diego, CA, United States, 4Life Sciences and Medicine, King's College London, London, United Kingdom
The impact of HA on tumour characteristics measured by MRI/E is not fully understood. We evaluated relationships between MRI biomarkers and histology in saline (HA present) and PEGPH20 treated (HA absent) breast tumours. ADC had the strongest association with HA, reaffirming that ADC is the most sensitive biomarker of tumour response to PEGPH20. MTR negatively correlated with HA, likely due to a HA-mediated dilution of MT-inducing components including collagen. MRE-derived elasticity (Gd) did not directly correlate with HA, however, HA degradation reduced the contribution of collagen to tumour viscoelasticity and may shift the sensitivity of Gd to the cellular compartment.
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