Abstract #0549

Investigating the contribution of hyaluronan (HA) to the breast tumour microenvironment using multiparametric MRI and histology

Emma L Reeves¹, Jin Li¹, Konstantinos Zormpas-Petridis¹, James Sullivan², Craig Cummings¹, Barbara Blouw³, David Kang³, Ralph Sinkus⁴, Jeffrey C Bamber¹, Yann Jamin¹, and Simon P Robinson¹

¹Radiotherapy & Imaging, Institute of Cancer Research, London, United Kingdom, ²Royal Marsden NHS Foundation Trust, London, United Kingdom, ³Halozyme Therapeutics, San Diego, CA, United States, ⁴Life Sciences and Medicine, King's College London, London, United Kingdom

Synopsis

The impact of HA on tumour characteristics measured by MRI/E is not fully understood. We evaluated relationships between MRI biomarkers and histology in saline (HA present) and PEGPH20 treated (HA absent) breast tumours. ADC had the strongest association with HA, reaffirming that ADC is the most sensitive biomarker of tumour response to PEGPH20. MTR negatively correlated with HA, likely due to a HA-mediated dilution of MT-inducing components including collagen. MRE-derived elasticity (G_d) did not directly correlate with HA, however, HA degradation reduced the contribution of collagen to tumour viscoelasticity and may shift the sensitivity of G_d to the cellular compartment.

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