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Abstract #0557

Simultaneous perfusion, diffusion, T2*, and T1 mapping with MR Fingerprinting (MRF-PDT)

Hongli Fan1,2, Lisa Bunker3, Alexandra Zezinka Durfee3, Xiaohong Joe Zhou4, Argye E. Hillis3, and Hanzhang Lu1,2,5
1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Center for Magnetic Resonance Research and Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States, 5F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Quantitative mapping of brain perfusion, diffusion, T2*, and T1 has a broad range of clinical applications. The present work aims to develop a novel pulse sequence that can simultaneously map perfusion, diffusion, T2* and T1 with MR fingerprinting, dubbed MRF-PDT, with a total scan time of <6 minutes. This technique was first demonstrated on healthy volunteers, then on two patients with ischemic stroke. All maps derived from MRF-PDT exhibited the expected image contrasts with quantitative values consistent with those reported in literature. In addition, test-retest studies confirmed the reproducibility of the proposed technique.

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