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Abstract #0570

A 320 km Hyperpolarization Journey: performing [U-13C, d7]glucose DNP in Copenhagen and Hyperpolarized 13C-MR in Aarhus

Andrea Capozzi1,2, Magnus Karlsson2, Esben Søvsø Szocska Hansen3, Juan Diego Sanchez2, Christoffer Laustsen3, Mathilde Hauge Lerche2, Jacques Van Der Klink1, and Jan Henrik Ardenkjær-Larsen2
1Physics, EPFL, Lausanne, Switzerland, 2Technical University of Denmark, Kgs. Lyngby, Denmark, 3Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark


Dissolution DNP polarizers are expensive, technically demanding and require trained personnel. At the same time, hyperpolarized MR tracers have a half-life short enough to need the polarizer to be placed as close as possible to the MRI scanner. Similarly to PET tracers, being able to receive on demand hyperpolarized contrast agents from a centralized facility would solve this major shortcoming and boost the diffusion of hyperpolarized MR on a wider scale. In this work, using UV-induced non-persistent radicals and purpose build hardware, we demonstrate the first “across-cities-dDNP” experiment.

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