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Abstract #0571

Methodological advances in serial hyperpolarized carbon-13 (HP-13C) metabolic imaging of patients with glioma 

Adam W Autry1, Sana Vaziri1, Jeremy W Gordon1, Marisa LaFontaine1, Hsin-Yu Chen1, Yaewon Kim1, Javier Villanueva-Meyer1, Susan M Chang2, Jennifer Clarke2,3, Nancy A Oberheim-Bush2,3, Duan Xu1, Janine M Lupo1, Peder EZ Larson1, Daniel B Vigneron1,4, and Yan Li1
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States, 3Department of Neurology, University of California San Francisco, San Francisco, CA, United States, 4Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States

Synopsis

This study aimed to improve hyperpolarized carbon-13 (HP-13C) metabolic imaging methodologies for serial monitoring of patients with malignant brain tumors. Several analyses were pursued among 29 patients diagnosed with gliomas and 7 volunteers. Implementation of atlas-based prescription of echo-planar imaging (EPI) demonstrated consistent volumetric coverage (dice:0.967-0.978) and improved hemispheric symmetry in modeled kinetics(p=0.006), which helped highlight tumor. A 2s versus 5s acquisition delay post injection of tracer increased the capture of [1-13C]pyruvate inflow dynamics(p=0.04), while reducing simulated kinetic modeling error. Post-acquisition FID-CSI spectra demonstrated improved referencing of [1-13C]pyruvate f0 using water versus a coil-embedded urea phantom(p=0.00003), thereby maximizing EPI excitation.

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