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Abstract #0575

Measuring Airflow Velocity in the Upper Airways with 129Xe Phase Contrast MRI: Feasibility in Pediatric Patients with Obstructive Sleep Apnea

Neil James Stewart1,2, Qiwei Xiao2,3, Matthew Willmering2,3, Keith McConnell3, Hui Wang4, Robert Fleck5, Jason Woods2,3, Raouf Amin3, and Alister Bates2,3,5,6
1POLARIS, Imaging Sciences, Department of Infection, Immunity & Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom, 2Center for Pulmonary Imaging Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 3Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 4MR Clinical Science, Philips, Cincinnati, OH, United States, 5Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 6Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, United States

Synopsis

We report preliminary HP 129Xe phase contrast (PC) MRI data in pediatric patients with obstructive sleep apnea; a common sleep-related breathing disorder caused by upper airway collapse. The feasibility and safety of 129Xe gas delivery through the patient’s anesthesia mask during tidal breathing under sedation (approximately sleep stage-2) was demonstrated. Dynamic spiral-based PC MRI (temporal resolution 0.5—1s) captured inspiratory and expiratory airflow, with sufficient sensitivity to identify flow features such as high-speed jets corresponding to regions of airway narrowing/obstruction on 1H anatomical MRI. With further data, our work may allow the development of optimized personalized treatment plans.

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