Quantification of reginal pulmonary ventilation changes in a longitudinal study with hyperpolarized gas MRI would be beneficial for clinicians evaluating treatment responses. While VDP is a sensitive measure of global lung ventilation, regional ventilation information inherent in imaging is lost. In this work, we present a method of performing voxel-wise comparisons in 3He MRI and producing regional ventilation change maps in asthma patients following bronchodilation with either short-acting or long-acting beta agonists at three timepoints. Regional change maps were congruous with visual assessment of regional ventilation changes and showed the temporal effects of bronchodilator action in patients with severe asthma.
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