Abstract #0579

Influence of electric field and axon geometry on peripheral nerve stimulation chronaxie

Natalie G Ferris^1,2, Valerie Klein^3,4, Bastien Guérin^4,5, Lawrence L Wald^2,4,5, and Mathias Davids^3,4,5

¹Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA, United States, ²Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, United States, ³Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany, ⁴A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ⁵Harvard Medical School, Boston, MA, United States

Synopsis

We calculate the impact of peripheral nerve geometry (bend angle, radius of curvature, and axon diameter) and electric field characteristics (hot-spot amplitude and extent) on the chronaxie of nerve stimulation to better understand the variability in experimental chronaxie values seen with MRI gradient coils.

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