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Abstract #0579

Influence of electric field and axon geometry on peripheral nerve stimulation chronaxie

Natalie G Ferris1,2, Valerie Klein3,4, Bastien Guérin4,5, Lawrence L Wald2,4,5, and Mathias Davids3,4,5
1Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA, United States, 2Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, United States, 3Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany, 4A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 5Harvard Medical School, Boston, MA, United States


We calculate the impact of peripheral nerve geometry (bend angle, radius of curvature, and axon diameter) and electric field characteristics (hot-spot amplitude and extent) on the chronaxie of nerve stimulation to better understand the variability in experimental chronaxie values seen with MRI gradient coils.

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