Detecting tract-specific abnormalities in individual patients with epilepsy using fixel-based analysis
Remika Mito1, Mangor Pedersen2, Robert Smith1,3, Donna Parker1, Leonid Churilov4, David Vaughan1,3,5, and Graeme Jackson1,3,5
1Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia, 2Department of Psychology and Neuroscience, Auckland University of Technology, Auckland, New Zealand, 3Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia, 4Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia, 5Department of Neurology, Austin Health, Melbourne, VIC, Australia
Fibre tract-specific abnormalities have been identified in various neurological disorders and conditions using fixel-based analysis. However, for this technique to be useful in clinical practice, such abnormalities should be detectable in individual patients. In this work, we apply the fixel-based analysis framework to detect fibre density and cross-sectional changes in individual patients with varying epilepsy diagnoses. Abnormalities could be detected in individual epilepsy patients, both at the tract level, and at the fixel-level, with different patterns of tract-based abnormality observed across the different epilepsy syndromes. This information could be clinically valuable when examining individual patients.
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