Imaging Neuronal Activity at Fast Timescales in Humans using MR Elastography
Shruti Mishra1,2, Bin Deng2,3,4, W. Scott Hoge1,2,3, Yanmei Tie2,5, Giacomo Annio6, Ralph Sinkus6, and Samuel Patz1,2
1Radiology, Brigham & Women's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 4Radiology, Massachusetts General Hospital, Boston, MA, United States, 5Neurosurgery, Brigham & Women's Hospital, Boston, MA, United States, 6Laboratory for Vascular Translational Science (LVTS), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France
A stimulus-interleaved magnetic resonance elastography (MRE) sequence was utilized to demonstrate fast functionally mediated localized changes in shear wavelength during a motor task. Four healthy adult subjects underwent a visual-cue mediated right-hand finger-tapping task, switching between tapping and no-tapping blocks every 2 seconds. Areas of greatest significance between the stimulus states were localized to the left primary motor cortex. A decreased stiffness of ~30% was observed during task performance compared to rest. Compared to traditional BOLD fMRI with a 20-second block, functional MRE areas of greatest statistical difference demonstrated greater percentage change and greater spatial localization.
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