A stimulus-interleaved magnetic resonance elastography (MRE) sequence was utilized to demonstrate fast functionally mediated localized changes in shear wavelength during a motor task. Four healthy adult subjects underwent a visual-cue mediated right-hand finger-tapping task, switching between tapping and no-tapping blocks every 2 seconds. Areas of greatest significance between the stimulus states were localized to the left primary motor cortex. A decreased stiffness of ~30% was observed during task performance compared to rest. Compared to traditional BOLD fMRI with a 20-second block, functional MRE areas of greatest statistical difference demonstrated greater percentage change and greater spatial localization.
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