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Abstract #0594

T2*-weighted dual-polarity skipped-CAIPI 3D-EPI: 400 microns isotropic whole-brain QSM at 7 Tesla in 6 minutes

Rüdiger Stirnberg1, Andreas Deistung2, and Tony Stöcker1,3
1German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 2University Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Halle, Germany, 3Department of Physics and Astronomy, University of Bonn, Bonn, Germany


We propose a dual-polarity readout technique to eliminate residual segmentation artifacts in interleaved multi-shot EPI despite established echo time shifting. The method only requires retrospective averaging of two or more complex-valued images acquired with alternating EPI readout polarity across measurements. The approach has been integrated into a custom skipped-CAIPI 3D-EPI sequence, combining highly segmented EPI with CAIPIRINHA parallel imaging. We present dual-polarity skipped-CAIPI 3D-EPI for ultrahigh-resolution, rapid, motion-robust whole-brain T2*-weighted imaging and quantitative susceptibility mapping at 7 Tesla. We demonstrate its capability to acquire exquisite imaging contrast at 0.7mm and 0.4mm isotropic resolution in only 1:15 and 6:14 [min:s], respectively.

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