Abstract #0595

Investigating the relationship between cortical myelin and functional brain activity

Eleonora Patitucci¹, Michael Germuska¹, Valentina Tomassini^2,3,4,5,6, and Richard G Wise^1,2,3

¹School of Psychology, CUBRIC, Cardiff University, Cardiff, United Kingdom, ²Department of Neuroscience, Imaging and Clinical Sciences, University “G. d'Annunzio” of Chieti-Pescara, Chieti, Italy, ³Institute for Advanced Biomedical Technologies, University “G. d'Annunzio” of Chieti-Pescara, Chieti, Italy, ⁴MS Centre, Neurology Unit, “SS. Annunziata” University Hospital, Chieti, Italy, ⁵Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom, ⁶Helen Durham Centre for Neuroinflammation, University Hospital of Wales, Cardiff, United Kingdom

Synopsis

The role of cortical myelin for cortical function is still under debate. Here we investigate the relationship between cortical myelination (represented by R1) and functional activation (represented by BOLD-fMRI and arterial spin labelling CBF signals) during the execution of a motor task. We demonstrate associations between cortical myelination and functional activity in a subset of task-responding regions. We observe a decrease of the significance of these relationships in the deeper cortical layers.

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