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Abstract #0595

Investigating the relationship between cortical myelin and functional brain activity

Eleonora Patitucci1, Michael Germuska1, Valentina Tomassini2,3,4,5,6, and Richard G Wise1,2,3
1School of Psychology, CUBRIC, Cardiff University, Cardiff, United Kingdom, 2Department of Neuroscience, Imaging and Clinical Sciences, University “G. d'Annunzio” of Chieti-Pescara, Chieti, Italy, 3Institute for Advanced Biomedical Technologies, University “G. d'Annunzio” of Chieti-Pescara, Chieti, Italy, 4MS Centre, Neurology Unit, “SS. Annunziata” University Hospital, Chieti, Italy, 5Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom, 6Helen Durham Centre for Neuroinflammation, University Hospital of Wales, Cardiff, United Kingdom


The role of cortical myelin for cortical function is still under debate. Here we investigate the relationship between cortical myelination (represented by R1) and functional activation (represented by BOLD-fMRI and arterial spin labelling CBF signals) during the execution of a motor task. We demonstrate associations between cortical myelination and functional activity in a subset of task-responding regions. We observe a decrease of the significance of these relationships in the deeper cortical layers.

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