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Abstract #0596

Laminar profiling in advanced susceptibility imaging reveals variations in iron and myelin concentrations

Subin Lee1, Hyeong-Geol Shin1, and Jongho Lee1
1Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of


The in-vivo imaging of iron and myelin concentrations along cortical laminae in the brain has significance in advancing knowledge about the roles of iron and myelin in brain function and in disease. In this study, we apply χ-separation, a recently developed advanced susceptibility imaging method, to explore changes in iron and myelin content throughout the cortex and into the white matter. Our findings show that iron and myelin peak at different laminar surfaces and that there is regional differences in the intensity profiles. The results suggest regional and laminar variation of iron and myelin throughout the brain.

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