Abstract #0597

Synthetic MRI with MR-STAT: results from a clinical trial

Jordi P.D. Kleinloog^1,2, Stefano Mandija^1,2, Federico D'Agata³, Oscar van der Heide^1,2, Beyza Koktas¹, Sarah M. Jacobs⁴, Cornelis A.T. van den Berg^1,2, Jeroen Hendrikse², Anja G. van der Kolk², and Alessandro Sbrizzi^1,2

¹Computational Imaging Group for MR diagnostic and therapy, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Radiotherapy, University Medical Centre Utrecht, Utrecht, Netherlands, ³Department of Neurosciences, University of Turin, Turin, Italy, ⁴Department of Radiology and Nuclear Medicine, University Medical Centre Utrecht, Utrecht, Netherlands

Synopsis

Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) reconstructs multiple quantitative MR parameters from a single fast scan. This quantitative information can be leveraged for several purposes, including the synthetization of clinically desired image contrasts. Preliminary results of the first clinical trial using MR-STAT in patients with neurological diseases show that the synthetically generated contrast images (i.e., T1w, T2w, PDw and FLAIR) were acceptable for diagnostic use (5-point Likert scale ≥ 3), although the score was lower compared to conventional contrasts. This highlights the potential of MR-STAT to provide synthetic contrasts on top of quantitative maps, while reducing scan time.

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