Synthetic MRI with MR-STAT: results from a clinical trial
Jordi P.D. Kleinloog1,2, Stefano Mandija1,2, Federico D'Agata3, Oscar van der Heide1,2, Beyza Koktas1, Sarah M. Jacobs4, Cornelis A.T. van den Berg1,2, Jeroen Hendrikse2, Anja G. van der Kolk2, and Alessandro Sbrizzi1,2
1Computational Imaging Group for MR diagnostic and therapy, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Radiotherapy, University Medical Centre Utrecht, Utrecht, Netherlands, 3Department of Neurosciences, University of Turin, Turin, Italy, 4Department of Radiology and Nuclear Medicine, University Medical Centre Utrecht, Utrecht, Netherlands
Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) reconstructs multiple quantitative MR parameters from a single fast scan. This quantitative information can be leveraged for several purposes, including the synthetization of clinically desired image contrasts. Preliminary results of the first clinical trial using MR-STAT in patients with neurological diseases show that the synthetically generated contrast images (i.e., T1w, T2w, PDw and FLAIR) were acceptable for diagnostic use (5-point Likert scale ≥ 3), although the score was lower compared to conventional contrasts. This highlights the potential of MR-STAT to provide synthetic contrasts on top of quantitative maps, while reducing scan time.
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