Abstract #0607
Reduced Field-of-View Intravoxel Incoherent Motion of the Human Pancreas Reflects Biphasic Response to Glucose Ingestion
Chengyue Wu1, Thomas E Yankeelov1,2,3,4,5,6, and John Virostko1,2,3,4
1Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX, United States, 2Livestrong Cancer Institutes, The University of Texas at Austin, Austin, TX, United States, 3Department of Diagnostic Medicine, The University of Texas at Austin, Austin, TX, United States, 4Department of Oncology, The University of Texas at Austin, Austin, TX, United States, 5Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, United States, 6Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Synopsis
Monitoring of the pancreatic islet is needed to assess individuals at risk for developing diabetes and facilitate development of islet-directed therapies. Pancreatic islets may be detectable due to their high vascularity. We imaged pancreas perfusion using both whole field-of-view and reduced field-of-view Intravoxel Incoherent Motion (IVIM) and found that the reduced field-of-view technique achieved similar image quality in half the time. We then performed a reduced field-of-view IVIM acquisition on four healthy controls. We found that pancreas perfusion increased dynamically in response to oral glucose challenge, exhibiting a biphasic increase that parallels the time course of insulin secretion.
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