Abstract #0607

Reduced Field-of-View Intravoxel Incoherent Motion of the Human Pancreas Reflects Biphasic Response to Glucose Ingestion

Chengyue Wu¹, Thomas E Yankeelov^1,2,3,4,5,6, and John Virostko^1,2,3,4

¹Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX, United States, ²Livestrong Cancer Institutes, The University of Texas at Austin, Austin, TX, United States, ³Department of Diagnostic Medicine, The University of Texas at Austin, Austin, TX, United States, ⁴Department of Oncology, The University of Texas at Austin, Austin, TX, United States, ⁵Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, United States, ⁶Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Synopsis

Monitoring of the pancreatic islet is needed to assess individuals at risk for developing diabetes and facilitate development of islet-directed therapies. Pancreatic islets may be detectable due to their high vascularity. We imaged pancreas perfusion using both whole field-of-view and reduced field-of-view Intravoxel Incoherent Motion (IVIM) and found that the reduced field-of-view technique achieved similar image quality in half the time. We then performed a reduced field-of-view IVIM acquisition on four healthy controls. We found that pancreas perfusion increased dynamically in response to oral glucose challenge, exhibiting a biphasic increase that parallels the time course of insulin secretion.

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