Meeting Banner
Abstract #0606

Dynamics of insulin secretion and pancreatic blood-flow: a simultaneous ASL perfusion imaging / hyperglycemic clamp study

Manuel Taso1, Donald C Simonson2, Lauren Phung1, Colleen McGrath1, Stephanie Waldman1, Fotini Papadopoulou1, and David C Alsop1
1Division of MRI Research, department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States


Loss of β-cell function and mass are hallmarks of type-1 and type-2 diabetes. Non-invasive imaging of endocrine pancreatic function would provide valuable insights into the degree and temporal patterns of endocrine dysfunction. For this purpose, Arterial Spin Labeling (ASL) is a uniquely suited non-invasive technique. We therefore conducted a dynamic ASL study during a hyperglycemic clamp to explore the dynamics of insulin secretion and pancreatic blood-flow.

This study showed that hyperglycemia and arginine-stimulated insulin secretion causes an increase in pancreatic perfusion and that the rate of insulin concentration change seems to be driving perfusion changes rather than absolute concentration.

This abstract and the presentation materials are available to members only; a login is required.

Join Here