Loss of β-cell function and mass are hallmarks of type-1 and type-2 diabetes. Non-invasive imaging of endocrine pancreatic function would provide valuable insights into the degree and temporal patterns of endocrine dysfunction. For this purpose, Arterial Spin Labeling (ASL) is a uniquely suited non-invasive technique. We therefore conducted a dynamic ASL study during a hyperglycemic clamp to explore the dynamics of insulin secretion and pancreatic blood-flow.
This study showed that hyperglycemia and arginine-stimulated insulin secretion causes an increase in pancreatic perfusion and that the rate of insulin concentration change seems to be driving perfusion changes rather than absolute concentration.
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