Neonatal hypoxic ischemic encephalopathy (HIE) is a serious neurological condition, representing a primary cause of neonatal death and developmental impairment. In newborns with HIE, hyperperfusion is related to severe adverse outcomes, but less is known about the link between perfusion and mild to moderate developmental impairments. Using a voxelwise correlation analysis, we investigated the link between ASL perfusion in newborns with HIE and developmental outcome at 2 years. A more adverse outcome was associated with hyperperfusion across the whole brain. A better cognitive outcome was associated with lower perfusion in the bilateral basal ganglia, thalamus, hippocampus and cerebellum.
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