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Abstract #0612

Hyperperfusion on arterial spin labelling is associated with cognitive impairment in infants with neonatal hypoxic ischemic encephalopathy

Ruth O'Gorman Tuura1, Raimund Kottke2, Barbara Brotschi3, Carola Sabandal4, Cornelia Hagmann3, and Beatrice Latal5
1Center for MR Research, University Children's Hospital, Zurich, Switzerland, 2Radiology, University Children's Hospital, Zurich, Switzerland, 3Neonatology and Pediatric Intensive Care, University Children's Hospital, Zurich, Switzerland, 4Anaesthesia, University Children's Hospital, Zurich, Switzerland, 5Child Development Center, University Children's Hospital, Zurich, Switzerland


Neonatal hypoxic ischemic encephalopathy (HIE) is a serious neurological condition, representing a primary cause of neonatal death and developmental impairment. In newborns with HIE, hyperperfusion is related to severe adverse outcomes, but less is known about the link between perfusion and mild to moderate developmental impairments. Using a voxelwise correlation analysis, we investigated the link between ASL perfusion in newborns with HIE and developmental outcome at 2 years. A more adverse outcome was associated with hyperperfusion across the whole brain. A better cognitive outcome was associated with lower perfusion in the bilateral basal ganglia, thalamus, hippocampus and cerebellum.

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