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Abstract #0613

Resting-state functional connectivity reductions in the cingulate gyrus in HIV exposed uninfected neonates

Jia Fan1,2, Fleur Warton1,2, Samantha Fry3, Mark Cotton3, Sandra Jacobson1,4, Joseph Jacobson1,4, Christopher Molteno5, Francesca Little6, Andre van der Kouwe1,7,8, Barbara Laughton3, and Ernesta Meintjes1,2,9
1Biomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa, 2Neuroscience Institute, University of Cape Town, Cape Town, South Africa, 3Family Centre for Research with Ubuntu, Department of Paediatrics and Child Health and Tygerberg Children’s Hospital, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa, 4Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States, 5Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa, 6Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa, 7A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 8Department of Radiology, Harvard Medical School, Boston, MA, United States, 9Cape Universities Body Imaging Centre, University of Cape Town, Cape Town, South Africa


Aggressive combination antiretroviral treatment in pregnancy has significantly reduced new perinatal HIV infections giving rise to a growing population of HIV exposed uninfected (HEU) children. Children who are HEU demonstrate neurodevelopmental delay compared to their HIV-unexposed uninfected (HUU) peers. We examined resting-state functional connectivity (RSFC) in neonates exposed to HIV and ART in utero and perinatally using resting-state fMRI. Ten standard resting-state networks were identified from independent component analysis. Voxelwise group comparison between neonates who are HEU and HUU revealed localized RSFC reductions in the cingulate gyrus within 3 networks: medial somatosensory, and anterior and posterior default mode networks.

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