DCE-MRI biomarkers such as change in median Ktrans have a proven role in drug development in phase I/II trials. There is current interest in using approaches such as radiomics to extract additional information relating to spatial heterogeneity from images and one emerging application is to apply these analyses to clinical trial data where imaging is used to monitor pharmacodynamic change in the tumour microenvironment. Here, we explore the properties of radiomics features extracted from maps of Ktrans and aim to identify features that are repeatable at baseline, show consistent treatment effect and provide additional, independent information to the median Ktrans.
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