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Abstract #0620

DCE-MRI with free-breathing compressed sensing VIBE for predicting chemotherapy response and patient outcome in pancreatic adenocarcinoma

Yoshihiko Fukukura1, Fumitaka Ejima1, Takuro Ayukawa1, Kiyohisa Kamimura1, Masanori Nakajo1, Hiroaki Nagano1, Koji Takumi1, Marcel Dominik Nickel2, Hiroshi Imai3, and Takashi Yoshiura1
1Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, 2MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, 3Siemens Healthcare K.K., Tokyo, Japan


This study focused on the feasibility of dynamic contrast-enhanced MRI (DCE-MRI) with motion-resolved compressed sensing T1-weighted volumetric interpolated breath-hold examination (CS-VIBE) for prediction of treatment response to chemotherapy and patient outcome in pancreatic ductal adenocarcinoma (PDAC). Our results showed tumor ve was significantly higher in the response group than in the non-response group and was an independent predictor of progression-free survival in patients with PDAC treated with chemotherapy. These results suggest that DCE-MRI obtained with CS-VIBE may be useful for predicting treatment response to chemotherapy and patient outcome in PDAC.

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