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Abstract #0621

Bias-free T1 Mapping via Simultaneously Estimating Bloch-Siegert and Magnetization Transfer Effects

Albert Jang1, Paul K Han1, Chao Ma1, Georges El Fakhri1, and Fang Liu1
1Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States


T1 maps obtained using fast steady-state sequences are usually sensitive to B1+ inhomogeneity and MT effects. We propose a novel method to achieve simultaneously B1+- and MT-corrected T1 quantification by introducing off-resonance RF pulses that create two effects: 1) direct saturation of macromolecules and 2) B1+ dependent Bloch-Siegert phase shift. This method, termed BTS (Bloch-Siegert and magnetization transfer simultaneously), is presented and validated in both simulations and experiments, correcting for T1 bias induced from B1+ inhomogeneity and MT effects.

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