Rapid quantitative magnetization transfer imaging: utilizing the hybrid state and the generalized Bloch model
Jakob Assländer1,2, Cem Gultekin3, Xiaoxia Zhang1,2, Quentin Duchemin4, Kangning Liu5, Robert WE Charlson6, Timothy Shepherd1, Carlos Fernandez-Granda3,5, and Sebastian Flassbeck1,2
1Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research, New York University School of Medicine, New York, NY, United States, 3Courant Institute of Mathematical Sciences, New York University, New York, NY, United States, 4Laboratoire d’analyse et de mathématiques appliquées, Université Gustave Eiffel, Paris, France, 5Center for Data Science, New York University, New York, NY, United States, 6Multiple Sclerosis Comprehensive Care Center, Department of Neurology, New York University School of Medicine, New York, NY, United States
We combine two recently proposed biophysical models, the hybrid state and the generalized-Bloch model, to describe magnetization transfer. Combined into a single model, they facilitate quantitative magnetization transfer imaging of the whole brain with 1mm isotropic resolution in 12 minutes. We optimized an MR-Fingerprinting-like pulse sequence, and validated the approach in two multiple sclerosis patients and two controls.
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