Studies on temporal diffusion characteristics can reveal a wealth of tissue microstructural information for disease evaluation, but typically require a long scan time because multiple diffusion times are need with each requiring a separate acquisition acquire. We herein report a time-efficient pulse sequence that acquires multiple diffusion-weighted images with different diffusion times in a single shot by utilizing multiple stimulated echoes with variable flip angles. This technique has been implemented on a 3T human scanner and successfully demonstrated in a quantitative diffusion phantom, the human brain gray and white matters, and the prostate peripheral zone and central grand.
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