The liver takes a central role in the regulation of glucose homeostasis by storing glucose in the fed state and releasing it during food abstinence. As a consequence, the liver is critically involved in glucose homeostasis disorders. We propose a novel non-invasive approach combining Deuterium Metabolic Imaging (DMI) with 13C-MRS at 7 T to dynamically map hepatic glucose metabolism. Preliminary results support technical feasibility and provide first insights into distinct hepatic glucose profiles in patients with dysregulated glucose homeostasis. The proposed approach may open new avenues for a better understanding of pathophysiology of glucose dysregulation and development of targeted treatments.
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