Real-time observation of postprandial hepatic glucose metabolism with interleaved 2H Metabolic Imaging and 13C-MRS at 7 T
Simone Poli1,2, Ahmed Fahiem Emara3, Edona Ballabani3, Angeline Buser3, Michele Schiavon4, David Herzig3, Chiara Dalla Man4, Luc Tappy3, Roland Kreis1,2, and Lia Bally3
1Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, 2Translational Imaging Center, sitem-insel, Bern, Switzerland, 3Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism UDEM, Insel Hospital, University Hospital Bern, Bern, Switzerland, 4Department of Information Engineering (DEI), University of Padova, Padova, Italy
The liver takes a central role in the regulation of glucose homeostasis by storing glucose in the fed state and releasing it during food abstinence. As a consequence, the liver is critically involved in glucose homeostasis disorders. We propose a novel non-invasive approach combining Deuterium Metabolic Imaging (DMI) with 13C-MRS at 7 T to dynamically map hepatic glucose metabolism. Preliminary results support technical feasibility and provide first insights into distinct hepatic glucose profiles in patients with dysregulated glucose homeostasis. The proposed approach may open new avenues for a better understanding of pathophysiology of glucose dysregulation and development of targeted treatments.
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