Abstract #0627

Addressing Concomitant Gradient Phase Errors in Chemical Shift-Encoded MRI with a Pass-Specific Phase Fitting Method

Nathan Tibbitts Roberts, BS^1,2, Diego Hernando, PhD^1,2,3,4, Nikolaos Panagiotopoulos, MD¹, and Scott B Reeder, MD, PhD^1,3,4,5,6

¹Radiology, University of Wisconsin - Madison, Madison, WI, United States, ²Electrical and Computer Engineering, University of Wisconsin - Madison, Madison, WI, United States, ³Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States

Synopsis

This work presents a complex-based fitting method to address concomitant gradient (CG) phase errors for time-interleaved (i.e., multi-pass) chemical shift-encoded (CSE) MRI estimation of proton density fat fraction (PDFF) and R2* through a joint estimation of pass-specific phase terms. The proposed method does not require prior knowledge of gradient waveforms. The proposed fitting method removed significant PDFF and R2* estimation errors in both phantom and in vivo evaluations away from isocenter. An evaluation in 29 clinical liver datasets demonstrated reduced PDFF bias and variability (8.4% improvement in the coefficient of variation), even when the imaging volume was centered at isocenter.

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