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Abstract #0630

Deuterium labeling enables non-invasive 3D proton MR imaging of glucose and neurotransmitter metabolism in the human brain

Petr Bednarik1, Dario Goranovic1, Alena Svatkova2, Fabian Niess1, Lukas Hingerl1, Bernhard Strasser1, Dinesh Deelchand3, Benjamin Spurny-Dworak4, Siegfried Trattnig1, Gilbert Hangel1,5, Thomas Scherer2, Rupert Lanzenberger4, and Wolfgang Bogner1
1High Field MR Center, Medical University of Vienna, Vienna, Austria, 2Department of Medicine III, Medical University of Vienna, Vienna, Austria, 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 4Department of Psychiatry ans Psychotherapy, Medical University of Vienna, Vienna, Austria, 5Department of Neurosurgery, Medical University of Vienna, Vienna, Austria


Recent studies have proposed deuterium (2H)-Magnetic Resonance Spectroscopic Imaging (MRSI) as a reliable, non-invasive, and safe method to quantify the human metabolism of 2H-labeled substrates such as glucose and their downstream metabolism and address the major drawbacks of positron emission tomography or carbon (13C)-MRS. Here, we pioneered a dynamic proton 3D (1H)-MRSI for indirect 2H-measurements in humans. In contrast to 2H-MRS(I), the method provides higher sensitivity and chemical specificity to differentiate glutamate, glutamine, and gamma-aminobutyric acid deuterated at specific molecular positions while simultaneously mapping both labeled and unlabeled metabolites without specialized hardware after peroral ingestion of 2H-labeled glucose.

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