39K/23Na MRI detects changes in muscular ion concentrations after exercise and in delayed-onset muscle soreness
Lena V. Gast1, Laura-Marie Baier1, Oliver Chaudry2, Christian R. Meixner1, Max Müller1, Klaus Engelke2,3, Michael Uder1, Armin M. Nagel1,4, and Rafael Heiß1
1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Department of Medicine 3, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 3Institute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 4Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
In this work, we investigated changes in the tissue potassium and sodium concentrations (TPC/TSC) of calf muscle tissue after exercise and in delayed-onset muscle soreness (DOMS) using combined 39K/23Na MRI. 14 healthy subjects were examined at baseline, directly after performing eccentric exercises and again 48h after exercise. Sodium and potassium concentrations showed inverse evolution, with changes in TSC being approximately twice as high as in TPC. Moreover, TPC was elevated in sore muscles without obvious edema, while TSC had returned to baseline or below. Thus, combined 39K/23Na MRI might help to elucidate physiological processes associated with DOMS and muscle fatigue.
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