Heterogeneity of multiple sclerosis lesions evidenced by 7T multiparametric sodium MRI
Mohamed Mounir EL MENDILI1,2, Bertrand AUDOIN1,2,3, Ben RIDLEY 1,2, Armin NAGEL4, Soraya GHERIB1,2, Lauriane PINI1,2, Patrick VIOUT1,2, Maxime GUYE1,2, Audrey RICO3, Clemence BOUTIERE3, Jean-Philippe RANJEVA 1,2, Jean PELLETIER1,2,3, Adil MAAROUF1,2,3, and Wafaa ZAARAOUI1,2
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital de la Timone, CEMEREM, Marseille, France, 3APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France, 4University Hospital Erlangen, Institute of Radiology, Erlangen, Germany
Inflammatory demyelinated lesions are a hallmark of multiple sclerosis (MS) and are the pathological substratum of clinical relapses. After their occurrence, neuropathological changes within lesions and lesion repair are variable and unpredictable. Chiefly, recovery from the first relapses is a key element of the long-term prognosis. Thus, in vivo exploration of lesion repair is of paramount importance.
The multi-TE sodium 7T MRI approach revealed that maintained sodium homeostasis within lesion is associated with a better recovery from relapses in MS. Sodium MRI appears to be a promising tool to assess in vivo preservation of neuronal function in MS.
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