Inflammatory demyelinated lesions are a hallmark of multiple sclerosis (MS) and are the pathological substratum of clinical relapses. After their occurrence, neuropathological changes within lesions and lesion repair are variable and unpredictable. Chiefly, recovery from the first relapses is a key element of the long-term prognosis. Thus, in vivo exploration of lesion repair is of paramount importance.
The multi-TE sodium 7T MRI approach revealed that maintained sodium homeostasis within lesion is associated with a better recovery from relapses in MS. Sodium MRI appears to be a promising tool to assess in vivo preservation of neuronal function in MS.
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