Abstract #0650

Fasciculus Axonal Connective Tissue (FACT) Mapping of Porcine Optic Nerve for Accurate Connectome Mapping at Viable Cost

Sudhir Kumar Pathak¹, Yijen L Wu^2,3, Vijay Saradhi Gorantla⁴, Fatih Zor⁴, Yalcin Kulahci⁴, Alan Watson⁵, Yongxin Zhao⁶, and Walter Schneider^1,7

¹Psychology, University of Pittsburgh, Pittsburgh, PA, United States, ²Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, ³Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Regenerative Medicine, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, United States, ⁵Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, United States, ⁶Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States, ⁷Neurosurgery, University of Pittsburgh, 15260, PA, United States

Synopsis

Accurate brain connectome mapping requires tracking fasciculus bundles of axons within tracts. In a porcine optic nerve harvested tissue, we optimized/tested MRI structural and diffusion imaging to demonstrate following fasciculi within the optic tract. On a 7T Bruker magnet, we can clearly identify fasciculus boarders and diffusion paths providing 29 micron precision MRI with clear tissue differentiation. We found that axons travel with no evidence of crossing fasciculi walls. This suggests Fasciculus Axonal Connective Tissue (FACT) imaging can provide full mapping of connectivity between cortical sources supporting comprehensive accurate mapping of connectivity in large mammal tract systems at viable cost.

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