In-vivo observations on structural aging of the inner ear – a two-center study
Franziska Thiessen1, Seyed-Ahmad Ahmadi2, Virginia Flanagin2, Joyce Bosmans3, Huseyin Ozenc Taskin4, Vincent Van Rompaey5, Geoffrey Karl Aguirre4, and Peter zu Eulenburg6
1Institut for Neuroradiology, LMU Munich, Munich, Germany, 2Center for Vertigo and Balance Disorders, LMU Munich, Munich, Germany, 3Translational Neurosciences, University of Antwerp, Antwerpen, Belgium, 4Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 5Department of Otorhinolaryngology-Head & Neck Surgery, University of Antwerp, Antwerpen, Belgium, 6Institute for Neuroradiology, LMU Munich, Munich, Germany
We are on the road to further the role of high-resolution structural neuroimaging in the diagnostics of the most prevalent vestibular disorders. After creating an in-vivo template and atlas space for the inner ear, we have no investigated structural aging across all cochlear and vestibular anatomical regions in a representative cohort (n=87). We significant reduction along the aging process for cochlear width and length as well as some semicircular canal dimensions. Total intracranial volume was a highly relevant covariate in our analysis. Aging also seemed to affect most neuroimaging quality parameters as well and had to be controlled for.
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