Abstract #0651

In-vivo observations on structural aging of the inner ear – a two-center study

Franziska Thiessen¹, Seyed-Ahmad Ahmadi², Virginia Flanagin², Joyce Bosmans³, Huseyin Ozenc Taskin⁴, Vincent Van Rompaey⁵, Geoffrey Karl Aguirre⁴, and Peter zu Eulenburg⁶

¹Institut for Neuroradiology, LMU Munich, Munich, Germany, ²Center for Vertigo and Balance Disorders, LMU Munich, Munich, Germany, ³Translational Neurosciences, University of Antwerp, Antwerpen, Belgium, ⁴Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ⁵Department of Otorhinolaryngology-Head & Neck Surgery, University of Antwerp, Antwerpen, Belgium, ⁶Institute for Neuroradiology, LMU Munich, Munich, Germany

Synopsis

We are on the road to further the role of high-resolution structural neuroimaging in the diagnostics of the most prevalent vestibular disorders. After creating an in-vivo template and atlas space for the inner ear, we have no investigated structural aging across all cochlear and vestibular anatomical regions in a representative cohort (n=87). We significant reduction along the aging process for cochlear width and length as well as some semicircular canal dimensions. Total intracranial volume was a highly relevant covariate in our analysis. Aging also seemed to affect most neuroimaging quality parameters as well and had to be controlled for.

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