Abstract #0653

Myelin Water Imaging Using a New 3D Short TR Adiabatic Inversion Recovery Prepared Short Echo Time (STAIR-STE) Sequence

Yajun Ma¹, Hyungseok Jang¹, Alecio F Lombardi ¹, Annie Hiniker ², Roland R Lee ¹, Eric Y Chang^1,3, Amy J Jak^3,4, Dawn Schiehser ^3,4, Alan N Simmons ^3,4, Brian P Head^3,5, Graeme M Bydder¹, and Jiang Du¹

¹Radiology, University of California, San Diego, San Diego, CA, United States, ²Pathology, University of California, San Diego, San Diego, CA, United States, ³Veterans Affairs San Diego Healthcare System, San Diego, CA, United States, ⁴Psychiatry, University of California, San Diego, San Diego, CA, United States, ⁵Anesthesiology, University of California, San Diego, San Diego, CA, United States

Synopsis

Myelin water imaging (MWI) has been proposed as a myelin-specific technique to quantify water trapped within or tightly bound to myelin bilayers and thus provides an indirect assessment of myelin content and integrity. In this study, we developed and evaluated a novel 3D short TR adiabatic inversion recovery prepared short echo time (STAIR-STE) Cones sequence for robust MWI on a clinical 3T scanner. Our results show that the 3D STAIR-STE Cones sequence robustly suppresses long-T2 intra/extracellular water signals and provides selective volumetric imaging and quantification of myelin water fraction in the whole brain.

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