Beyond Fractional Anisotropy: A Comparative Study of Myelin Water Fraction and Propagator Anisotropy in the Bonnet Macaque Brain
Laurel A Dieckhaus1, Courtney J Comrie1, Kelsey E McDermott2, Daniel T Gray2, Carol A Barnes2,3,4, and Elizabeth B Hutchinson1
1Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 2Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States, 3Psychology, Neurology and Neuroscience, University of Arizona, Tucson, AZ, United States, 4Psychology and Neurology, University of Arizona, Tucson, AZ, United States
White matter (WM) is commonly studied using the Diffusion Tensor Imaging (DTI) metric Fractional Anisotropy (FA), which has limitations especially in regions where more than one fiber population exists. We compared FA to diffusion techniques (Mean Apparent Propagator (MAP-MRI)) and relaxometry techniques (Myelin Water Fraction (MWF) and Bound Pool Fraction (BPF)) mapping in the normal bonnet macaque brain. The combination of histograms and correlation analysis revealed that MAP-MRI metric, Propagator Anisotropy (PA) and MWF may offer more information about WM than FA alone, while remaining relatively correlated with FA; while BPF did not have strong association with FA or MWF.
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