Abstract #0655

Assessing white matter maturation and integrity in children using multi-component 3D-MR Fingerprinting and diffusion imaging

Marta Lancione^1,2, Matteo Cencini^1,2, Elena Scaffei^1,3, Emilio Cipriano^1,4, Guido Buonincontri¹, Chiara Ticci¹, Rosa Pasquariello¹, Roberta Battini^1,5, Raffaello Canapicchi¹, Laura Biagi^1,2, Michela Tosetti^1,2, and Italian DEvelopmental Age Health Network (IDEA)⁶

¹IRCCS Stella Maris, Pisa, Italy, ²Imago7 Research Foundation, Pisa, Italy, ³Department of Neuroscience, Psychology, Drug Research and Child Health, Neurofarba, University of Florence, Florence, Italy, ⁴Department of Physics, University of Pisa, Pisa, Italy, ⁵Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ⁶Italian DEvelopmental Age Health Network (RETE IDEA Ministry of Health), Rome, Italy

Synopsis

New biomarkers for myelination could improve the understanding of neurodevelopmental diseases and their diagnosis and treatment. We quantified Myelin Water Fraction (MWF) using MRF in a cohort of children with leukoencephalopathies and age-matched controls and we compared it to DTI-based FA. We obtained normative curves of white matter development with both techniques. MWF discriminated between controls and patients with higher sensitivity than FA, it was more myelin-specific and independent of the degree of axonal packing. Thanks to short scan time and simultaneous acquisition of other quantitative maps, MRF-based MWF may represent a valuable tool to study developmental disorders.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.