Abstract #0659
Hyperpolarized 129Xe MR Imaging in Neonates with Bronchopulmonary Dysplasia: Feasibility and Challenges
Neil J Stewart1,2, Nara Higano2,3,4,5, Shanmukha Sai Mukthapuram3,6, Matthew M Willmering2,3, Anita Arnsperger7, Ronald Pratt4, Wolfgang Loew4, Madhwesha R Rao1, Rolf F Schulte8, Jim M Wild1, and Jason C Woods2,3,4,5
1POLARIS, Imaging Sciences, Department of Infection, Immunity & Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom, 2Center for Pulmonary Imaging Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 3Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 4Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 5Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, United States, 6The Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 7Division of Respiratory Care, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 8GE Healthcare, Munich, Germany
Synopsis
We report the first-ever experience in performing HP 129Xe MRI in neonates. The neonates had prematurity-related lung disease (bronchopulmonary dysplasia), a major cause of morbidity/mortality that remains poorly characterised. The feasibility of imaging during a short (<3s) breath-hold apnea was demonstrated. Spiral-based 129Xe ventilation imaging showed good image quality (SNR>20) and sufficient sensitivity to detect mild ventilation abnormalities. Dynamic 129Xe spectroscopy revealed the existence of resonances near the conventional tissue/plasma and red blood cells resonances observed in children and adults. With further data, our work may impact on the management of infant lung diseases in the neonatal period and beyond.
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