Analysis of dynamic lung OE-MRI is challenging due to the presence of substantial artefacts and poor SNR, particularly at 3 T. We propose a cyclical oxygen delivery scheme and ICA to separate the oxygen-enhancement signal from these confounding factors at 3 T. The proposed method extracts a well-defined oxygen-enhancement signal that removes confounds due to proton density changes, blood flow and motion. We also demonstrate the ability to resolve the opposite enhancement effects of the parenchymal and vascular OE-MRI signals to provide information on pulmonary vasculature and gas distribution. The method is shown to be sensitive to smoking status.
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