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Abstract #0667

Age-related changes in human skeletal muscle microstructure and architecture assessed by DT-MRI and their association with muscle strength

Donnie Cameron1,2, David A. Reiter3, Fatemeh Adelnia4, Ceereena Ubaida-Mohien5, Christopher M. Bergeron6, Seongjin Choi7, Kenneth W. Fishbein6, Richard G. Spencer6, and Luigi Ferrucci5
1Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 2Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Emory University School of Medicine, Atlanta, GA, United States, 4Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 5Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States, 6Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States, 7Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States


Here we apply diffusion-tensor-(DT)-MRI to study muscle microstructural and architectural changes with healthy ageing in 94 participants (median age=56, range=22-89yrs). Fractional anisotropy (FA) and mean diffusivity (MD), were calculated for 12 thigh muscles, as were pennation angle, fascicle length, fibre curvature, and physiological cross-sectional area (PCSA) for the rectus femoris and biceps femoris longus. Knee extension/flexion torques were also measured. FA and MD were significantly associated with age (β=0.34 and −0.34, p<0.05), as were architecture parameters. Pennation angle and PCSA were positively associated with strength. This may prove useful for studying muscle response to interventions designed to delay sarcopenia.

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