Abstract #0667

Age-related changes in human skeletal muscle microstructure and architecture assessed by DT-MRI and their association with muscle strength

Donnie Cameron^1,2, David A. Reiter³, Fatemeh Adelnia⁴, Ceereena Ubaida-Mohien⁵, Christopher M. Bergeron⁶, Seongjin Choi⁷, Kenneth W. Fishbein⁶, Richard G. Spencer⁶, and Luigi Ferrucci⁵

¹Norwich Medical School, University of East Anglia, Norwich, United Kingdom, ²Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Emory University School of Medicine, Atlanta, GA, United States, ⁴Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ⁵Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States, ⁶Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States, ⁷Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States

Synopsis

Here we apply diffusion-tensor-(DT)-MRI to study muscle microstructural and architectural changes with healthy ageing in 94 participants (median age=56, range=22-89yrs). Fractional anisotropy (FA) and mean diffusivity (MD), were calculated for 12 thigh muscles, as were pennation angle, fascicle length, fibre curvature, and physiological cross-sectional area (PCSA) for the rectus femoris and biceps femoris longus. Knee extension/flexion torques were also measured. FA and MD were significantly associated with age (β=0.34 and −0.34, p<0.05), as were architecture parameters. Pennation angle and PCSA were positively associated with strength. This may prove useful for studying muscle response to interventions designed to delay sarcopenia.

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