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Abstract #0670

Evaluating correlations of quantitative muscle MRI of leg muscles and clinical outcome measurements in patients with LGMD2A

Lara Schlaffke1, Marlena Rohm1, Robert Rehmann1,2, Anne-Katrin Güttsches1, Martijn Froeling3, Matthias Vorgerd1, and Johannes Forsting1
1Neurology, University Clinic Bergmannsheil Bochum gGmbH, Bochum, Germany, 2Neurology, Klinikum Dortmund, University Witten-Herdecke, Dortmund, Germany, 3Radiology, UMC Utrecht, Utrecht, Netherlands


Quantitative MRI (qMRI) techniques like Dixon fat-fraction (FF) and quantitative water-T2 relaxation time (T2) are promising non-invasive tools in the evaluation of neuromuscular diseases like LGMD2A. In this study, we were able to show moderate to strong correlations between quantitative MRI values, especially FF, with clinical outcome measures and daily life activities. Analysis of T2 relaxation time in non-fat-infiltrated leg muscles of LGMD2A patients showed a significantly higher water T2 values compared to healthy controls. Therefore, T2 relaxation times may offer an earlier detection of disease-related change of muscular tissue in limb girdle muscular dystrophy compared to irreversible fat-fractions.

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