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Abstract #0671

Quantitative MRI Analysis of Muscle Denervation

Tim Yiran Li1, Erin Argentieri2, Emily Pedrick2, Darryl B. Sneag2, and Ek T. Tan2
1Weill Cornell Medical College, New York, NY, United States, 2Hospital for Special Surgery, New York, NY, United States


Macroscopic muscle volume evaluation and quantitative MRI of diffusion microstructure may provide objective, longitudinal assessment of muscle denervation. Analysis of subjects with Parsonage-Turner syndrome (neuralgic amyotrophy) showed both reduced muscle volume and reduced muscle diameter. Macroscopic muscle volume demonstrated a strong positive correlation with microscopic diffusion-based muscle diameter, and a strong negative correlation with T2-mapping. Denervated muscles exhibited longitudinal changes in quantitative MRI metrics, whereas non-denervated (control) muscles showed minimal quantitative changes.

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