Macroscopic muscle volume evaluation and quantitative MRI of diffusion microstructure may provide objective, longitudinal assessment of muscle denervation. Analysis of subjects with Parsonage-Turner syndrome (neuralgic amyotrophy) showed both reduced muscle volume and reduced muscle diameter. Macroscopic muscle volume demonstrated a strong positive correlation with microscopic diffusion-based muscle diameter, and a strong negative correlation with T2-mapping. Denervated muscles exhibited longitudinal changes in quantitative MRI metrics, whereas non-denervated (control) muscles showed minimal quantitative changes.
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