Abstract #0672

Strain rates along the fiber are heterogeneously distributed over the length of lower leg muscles during dynamic exercise

Melissa Tamara Hooijmans¹, Thom T.J. Veeger², Valentina Mazzoli³, Hans C. van Assen⁴, Lukas M. Gottwald¹, Aart J. Nederveen¹, Jurriaan H. de Groot⁵, Gustav J. Strijkers⁶, and Hermien E. Kan^2,7

¹Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam Movement Sciences, Amsterdam, Netherlands, ²C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Radiology, Stanford University, Stanford, CA, United States, ⁴Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁵Department of Rehabilitation Medicine, Leiden University Medical Center, Leiden, Netherlands, ⁶Department of Biomedical Engineering and Physics, Amsterdam Movement Sciences, Amsterdam University Medical Center, Amsterdam, Netherlands, ⁷Duchenne Center Netherlands, Leiden, Netherlands

Synopsis

In this study we assessed strain rates along and close to perpendicular to the fiber in the lower-leg muscles, by combining 3D phase contrast with DTI-derived fiber orientations, during dynamic exercise with and without load. Our data revealed spatially heterogeneous strain rate patterns along the fiber within lower-leg muscles, with smallest and largest strain rates in the most proximal and distal segments of the Gastrocnemii muscles, respectively, and opposed (expansion and contraction) strain rate patterns between some of the Tibialis Anterior (TA) muscle compartments. Additional loading resulted in higher strain rates in TA compartments but lower in the Gastrocnemii muscles.

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