The value of water T2 relaxation time in the early detection of neuromuscular diseases: a retrospective biopsy-controlled analysis in 83 patients
Fabian Balsiger1, Noah Locher2, Benedikt Wagner1, and Olivier Scheidegger1,2
1Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, 2Centre for Neuromuscular Diseases, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
The diagnostic ability of quantitative water T2 mapping using multi-slice multi-echo sequences for the early detection of neuromuscular diseases (NMDs) was compared to fat-suppressed T2-weighted turbo inversion recovery magnitude (TIRM) MRI. Water T2 mapping had a significantly higher sensitivity and diagnostic ability in detecting muscle abnormalities than the subjective grading of TIRM MRI, prior to late-stage fatty infiltration signal alternations in T1-weighted MRI. Normal appearing TIRM MRI does not rule out disease activity in muscles in NMDs. Our findings suggest considering water T2 mapping over TIRM MRI for early detection of NMDs in clinical practice.
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