Abstract #0678

MRS to assess changes in total choline as a potential marker of treatment response to choline kinase inhibition in GL261 mouse glioblastomas

Sourav Bhaduri¹, Jack Sharkey¹, Soham Mukherjee¹, Edward J Delikatny², Sungheon G Kim³, and Harish Poptani¹

¹Centre for Preclinical Imaging, University of Liverpool, Liverpool, United Kingdom, ²Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Radiology, Weill Cornell Medical College, New York, NY, United States

Synopsis

This study investigates the effect of JAS239 on GL261 mouse glioblastoma using MRS. Higher reduction in Cho concentration and Cho/Cr ratios were observed in the tumour region than the contralateral normal brain after JAS239, indicating high sensitivity of MRS in as a pharmacodynamic marker of ChoK inhibition in glioblastomas with a potential of being an alternative treatment method.

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