MRS to assess changes in total choline as a potential marker of treatment response to choline kinase inhibition in GL261 mouse glioblastomas
Sourav Bhaduri1, Jack Sharkey1, Soham Mukherjee1, Edward J Delikatny2, Sungheon G Kim3, and Harish Poptani1
1Centre for Preclinical Imaging, University of Liverpool, Liverpool, United Kingdom, 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Radiology, Weill Cornell Medical College, New York, NY, United States
This study investigates the effect of JAS239 on GL261 mouse glioblastoma using MRS. Higher reduction in Cho concentration and Cho/Cr ratios were observed in the tumour region than the contralateral normal brain after JAS239, indicating high sensitivity of MRS in as a pharmacodynamic marker of ChoK inhibition in glioblastomas with a potential of being an alternative treatment method.
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