We report on an advanced mpMRI protocol for characterizing the cellular and vascular phenotype in an orthotopic mouse model of pediatric ependymoma (EPN). Using diffusion-weighted based cell-size imaging, iron-oxide based vessel-size imaging and quantitative T2-maps, we report on an EPN-specific phenotype, characterized by an increased cell size (S=14 microns), increased vessel density index (Q=0.54), and low ADC values (0.63x10-3). Radiation treatment (10 Gy) in combination with 5-fluorouracil chemotherapy resulted in a decrease of gross tumor volumes, tumor necrosis with decreased cell sizes and increased ADC values, as well as a dramatic vascular-inflammatory response (highly decreased Q and DT2 values).
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