Meeting Banner
Abstract #0679

Advanced Vessel- and Cell-Size MRI to Assess Chemo-Radiation Treatment Response in Pediatric Ependymoma Models

Natalie J Serkova1, Jane S Manalo2, Jenna L Steiner2, Andrea M Griesinger2, Angela Pierce2, Mark S Brown2, and Nicholas F Foreman3
1Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 2University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 3Children's Hospital Colorado, Aurora, CO, United States


We report on an advanced mpMRI protocol for characterizing the cellular and vascular phenotype in an orthotopic mouse model of pediatric ependymoma (EPN). Using diffusion-weighted based cell-size imaging, iron-oxide based vessel-size imaging and quantitative T2-maps, we report on an EPN-specific phenotype, characterized by an increased cell size (S=14 microns), increased vessel density index (Q=0.54), and low ADC values (0.63x10-3). Radiation treatment (10 Gy) in combination with 5-fluorouracil chemotherapy resulted in a decrease of gross tumor volumes, tumor necrosis with decreased cell sizes and increased ADC values, as well as a dramatic vascular-inflammatory response (highly decreased Q and DT2 values).

This abstract and the presentation materials are available to members only; a login is required.

Join Here