Abstract #0680

Assessing tumour haemodynamic heterogeneity and response to choline kinase inhibition using DCE-MRI in rodent models of glioblastoma

Sourav Bhaduri¹, Jack Sharkey¹, Clémentine Lesbats², Claire L. Kelly¹, Soham Mukherjee¹, Edward J Delikatny³, Sungheon G Kim⁴, and Harish Poptani¹

¹Centre for Preclinical Imaging, University of Liverpool, Liverpool, United Kingdom, ²Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom, ³Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁴Department of Radiology, Weill Cornell Medical College, New York, NY, United States

Synopsis

This study was designed to monitor changes in DCE-MRI based parameters K^trans, v_e, τ_i and F_p in pre-clinical GBM models in response to choline kinase inhibition using a cluster analysis approach. The study demonstrates that region-based clustered pharmacokinetic parameters obtained using DCE-MRI can be used for detecting and assessing tumour heterogeneities which may be useful in assessing therapeutic response.

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