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Abstract #0680

Assessing tumour haemodynamic heterogeneity and response to choline kinase inhibition using DCE-MRI in rodent models of glioblastoma

Sourav Bhaduri1, Jack Sharkey1, Clémentine Lesbats2, Claire L. Kelly1, Soham Mukherjee1, Edward J Delikatny3, Sungheon G Kim4, and Harish Poptani1
1Centre for Preclinical Imaging, University of Liverpool, Liverpool, United Kingdom, 2Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom, 3Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 4Department of Radiology, Weill Cornell Medical College, New York, NY, United States


This study was designed to monitor changes in DCE-MRI based parameters Ktrans, ve, τi and Fp in pre-clinical GBM models in response to choline kinase inhibition using a cluster analysis approach. The study demonstrates that region-based clustered pharmacokinetic parameters obtained using DCE-MRI can be used for detecting and assessing tumour heterogeneities which may be useful in assessing therapeutic response.

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